LIU Du-hu, LIU Wen-chao, YU Zhao-cai, FAN Li, ZHU Yan-guang, SHENG Rong,
XUE Yan, HUANG Ying Department of Oncology, Xijing Hospital of Fourth Military
Medical University PLA, Xi’an 710032, P.R.China
【ABSTRACT】
OBJECTIVE: To investigate the clinical effect of
coelom hyperthermia perfusion extracorporeal circulatory system in combination
with cisplatin in the treatment of malignant effusions caused by malignant
mesothelioma, alimentary tract carcinoma and lung cancer, METHODS: The
patients with malignant mesothelioma, lung cancer and alimentary tract carcinoma (including
liver cancer, gastric cancer, pancreatic cancer, and colon
cancer), diagnosed by pathological evidences or image and serum tumor markers， following malignant effusions， were treated by coelom
hyperthermia perfusion extracorporeal circulatory system in combination with
cisplatin. The treatment was performed 1 circulation per 48 h, and 1
cycle included 3 circulations, 21 d. The volume of effusions was examined at
the beginning and 1
cycle later. After 6 weeks, the efficacy was evafuated again, and
being followed up for 10 weeks. RESULTS:
1)There were 3 cases of complete response(CR), 2 cases of partial response(PR),
and 0 cases no effect (NE) in 5 cases of malignant mesothelioma after 1 cycle;
and the 2 cases of PR became CR after 2 cycles. Six weeks later, the effect on all
patients was CR. Following up for 10 weeks, the effusions had a relapse in 2
cases, 2)There were 25 cases of CR, 10 cases of PR, and 6 cases NE in 41 cases
of alimentary tract carcinoma accompanied by malignant effusions after 1 cycle,
the clinical profit rate was 85%. Following up for 10 weeks, there were 20 cases of CR,
10 cases of PR,, and 11 cases of NE, and the clinical profit rate was 73%.
3) There were 5 cases of CR, 2 cases of PR. and 1 cases NE in 8 cases of lung
cancer accompanied by malignant effusions after 1 cycle. Following up for 10
weeks, there were 4 cases of CR, 2 cases of PR, and 2 cases of NE, and the
clinical profit rate was 75%. CONCLUSION:
Coelom hyperthermia perfusion extracorporeal circulatory system in
combination with cisplatin can treat malignant effusions caused by malignant
mesothelioma, alimentary tract cancer (liver cancer, gastric cancer, colon
cancer) and lung cancer, and its curative effect is defined.
Chin J Cancer Prev Treat, 2009.16(5), 381-383
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